文章摘要

长链非编码RNA在肾癌中的研究进展

作者: 1张继威, 2蔡璐莹, 1夏舜尧, 1黄怡, 1修有成
1 哈尔滨医科大学附属第一医院泌尿外科，哈尔滨 150001
2 首都医科大学附属北京同仁医院超声诊断科，首都医科大学附属北京同仁医院，北京 100730
通讯: 修有成 Email: 626918215@qq.com
DOI: 10.3978/j.issn.2095-6959.2019.11.031
基金: 黑龙江省教育厅海外学人科研资助项目 (1254HQ014)。

摘要

长链非编码RNA(long non-coding RNA，lncRNA)广泛表达于生物体细胞中，是一类长度大于200 nt且无蛋白质编码功能的RNA。它调控多种疾病的发生发展，主要表现为肿瘤细胞的增殖、凋亡、侵袭和转移等方面。近年来，lncRNA与肾癌(renal cell carcinoma，RCC)的关系越来越受重视，随着lncRNA在RCC中的作用机制逐步揭开，为RCC的早期诊断、评估预后及研发新型靶向药物开辟了新思路。
关键词： 肾癌；长链非编码RNA；分子标志物；研究进展

Research progress of long non-coding RNA in renal cell carcinoma

Authors: 1ZHANG Jiwei, 2CAI Luying, 1XIA Shunyao, 1HUANG Yi, 1XIU Youcheng
1 Department of Urinary Surgery, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
2 Department of Ultrasound Diagnosis, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

CorrespondingAuthor: XIU Youcheng Email: 626918215@qq.com

DOI: 10.3978/j.issn.2095-6959.2019.11.031

Foundation: This work was supported by the Overseas Scholars Research Funding Project of Heilongjiang Provincial Education Department, China (1254HQ014).

Abstract

Long non-coding RNA (lncRNA) is widely expressed in living cells and is a type of RNA with a length greater than 200 nt and no protein coding function. It regulates the development of a variety of diseases, mainly in the proliferation, apoptosis, invasion and metastasis of tumor cells. In recent years, the relationship between lncRNA and renal cell carcinoma has been paid more and more attention. With the gradual uncovering of the mechanism of lncRNA in renal cell carcinoma, new ideas for early diagnosis, prognosis evaluation, and development of new targeted drugs for renal cell carcinoma have been opened.
Keywords： renal cell carcinoma; long non-coding; molecular marker; research progress

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