miR-34在肿瘤中的研究进展
| 作者: |
1朱泽民,
1徐涛,
1唐才喜
1 中南大学湘雅医学院附属株洲医院肝胆胰脾外科，湖南 株洲 412007 |
| 通讯: |
唐才喜
Email: tcx0826@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.11.030 |
| 基金: | 湖南省科技计划项目(2016SK4006)，湖南省医药卫生科研计划项目(c2016109)。 |
摘要
MicroRNA(miRNA)是一类高度保守的非编码调控的小分子单链RNA，控制多种人类必需基因的表达，参与各种信号通路，并在一些生物体内发挥重要的生物学作用。MiR-34作为特异性miRNA，在人类多种癌症中表达失调，与肿瘤抑制因子p53具有协同作用，在抑制肿瘤发生发展中起重要作用。近年来，miR-34在肿瘤中的作用日益受到关注，有望成为肿瘤治疗的新靶点。
关键词：
miRNA；miR-34；肿瘤；研究进展
Research progress of miR-34 in tumor
CorrespondingAuthor: TANG Caixi Email: tcx0826@163.com
DOI: 10.3978/j.issn.2095-6959.2019.11.030
Foundation: This work was supported by Hunan Province Funding Support for Science and Technology Program Projects (2016SK4006) and Hunan Medical and Health Research Program Project (c2016109), China.
Abstract
MicroRNA (miRNA) is a highly conserved single-stranded small non-coding RNA which controls the expression of many essential human genes, participates in a variety of signaling pathways, and plays an important biological role in some organisms. MiR-34, as a specific miRNA, is dysregulated in a variety of human cancers. Because of its synergistic effect with tumor suppressor p53, miR-34 plays an important role in inhibiting tumorigenesis and development. In recent years, the role of miR-34 in tumor has been paid more and more attention, and it is expected to become a new target of tumor therapy.
Keywords：
miRNA; miR-34; tumor; research progress