骨微环境在恶性肿瘤骨转移中的作用及进展
| 作者: |
1马晓婷,
1俞静
1 首都医科大学附属北京友谊医院肿瘤科，北京 100050 |
| 通讯: |
俞静
Email: yujing026@ccmu.edu.cn |
| DOI: | 10.3978/j.issn.2095-6959.2019.11.028 |
| 基金: | 国家自然科学基金(81774221)；首都卫生发展科研项目(2018-2-1113)；首都医科大学基础-临床科研合作基金(17JL14)；首都医科大学附属北京友谊医院科研启动基金(yyqdkt2016-4)。 |
摘要
恶性实体肿瘤，如前列腺癌、乳腺癌、肺癌、甲状腺癌和肾癌易于转移到骨，骨转移的发生严重影响患者的总生存率和生存质量。骨的微环境为癌细胞的黏附、定植和增殖营造了适宜的环境，骨微环境的变化可以为多种恶性肿瘤定向转移到骨创造条件。与骨微环境相关的许多生物因子在恶性肿瘤骨转移中发挥重要作用。
关键词：
骨转移；肿瘤；骨微环境；生物因子
Role and progression of bone microenvironment in the development of bone metastasis in malignant tumors
CorrespondingAuthor: YU Jing Email: yujing026@ccmu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2019.11.028
Foundation: This work was supported by the National Natural Science Foundation (81774221), Basic-Clinical Cooperation Program from Capital Medical University (17JL14)
Abstract
Malignant solid tumors, such as prostate, breast, lung, thyroid, renal carcinoma, are tend to metastasize to bone. It seriously affects the overall survival rate and quality of life of the patients. Bone microenvironment provides an appropriate environment for the adhesion, colonization and proliferation of cancer cells. Changes in bone microenvironment can create conditions for the directional metastasis of various malignant tumors to bone. In recent years, many studies have proved that many biological factors related to bone microenvironment play an important role in bone metastasis of malignant tumors.
Keywords：
bone metastases; tumor; bone microenvironment; biological factors