Objective: To explore the application of LERANS mode in health education for patients with diabetic retinopathy. Methods: A total of 124 patients with diabetic retinopathy who were hospitalized in our department from September 2017 to April 2018 were divided into two groups according to the time sequence of admission. Sixty-two patients who received treatment from September 2017 to December 2017 were selected as the control group, and received basic treatment combined with routine health education. Sixty-two patients who received treatment from January 2018 to April 2018 were selected as the observation group, and received basic treatment combined with LERANS health education. The self-care ability, self-efficacy, quality of life and therapeutic effect of the two groups were compared before and after intervention. Results: There was no significant difference in self-care ability, self-efficacy and quality of life between the two groups before intervention. The scores of self-care ability and self-efficacy in the observation group were significantly higher than those in the control group after intervention (P<0.05), and the scores of all dimensions and total scores of quality of life were significantly lower than those in the control group (P<0.05). The treatment effect of the observation group was significantly better than that of the control group (P<0.05). Conclusion: The LERANS health education mode can effectively improve the self-care ability and self-efficacy of diabetic retinopathy patients, improve their quality of life and treatment effect, which is worthy of further promotion in clinical practice.