Objective: To explore the effect of nutritional intervention on the nutritional status of patients with adjuvant chemotherapy after gastric cancer operation under the multidisciplinary cooperative case management model. Methods: This study was a randomized controlled study with single blindness. The random table was placed in an envelope and saved by nurses who did not participate in the study. According to the order of patient visits, the continuous random access code was assigned to the routine care group and case management mode group, the intervention time was 28 days. Objective to compare the changes of objective nutritional indicators (body weight, BMI, serum total protein, albumin), Nutritional Risk Score (NRS2002) and Patient-Generated Subjective Global Assessment (PG-SGA) before and after intervention. Results: The case management model of multidisciplinary cooperation was comparable to that of the conventional nursing group (P>0.05). After intervention, the patients with nutritional risk in the case management group were less than the routine care group (P<0.05). The nutritional condition were improved to intervention group measured by PG-SGA (P<0.05). There were significant differences in the total protein and albumin level between the group and the group in the case management model (P<0.05). Conclusion: Nutritional intervention in case management mode can improve nutritional status and reduce nutrition risk, but long-term intervention and follow-up are needed to verify its long-term effect.