β2 肾上腺素能受体基因A46G 和C79G 多态性与慢性阻塞性肺疾病发病关系的荟萃分析
| 作者: |
1付敏,
1谢伟见,
1吴成明
1 上海市闵行区吴泾医院呼吸内科，上海 200241 |
| 通讯: |
谢伟见
Email: 2316237956@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.10.016 |
摘要
目的：探讨β 2肾上腺素能受体基因(ADRB2)A46G，C79G多态性与慢性阻塞性肺疾病(chronic obstructive pulmonar y disease，COPD)的相关性。方法：首先通过检索PubMed和Embase来筛选符合要求的病例-对照研究，再用RevMan 5.0软件进行一系列综合定量分析，包括OR值，95%可信区间(CI)，异质性的检验以及敏感性分析。通过Stata 12.0软件来检测发表偏倚。结果：共收录9篇符合标准的研究，其中，对于ADRB2 A46G位点，收集1 037名COPD患者和1 134名对照者，对于ADRB2 C79G位点，收集1 156名COPD患者和1 026名对照者。在总体分析中，并没有发现这2个位点与COPD相关性有统计学意义。对于A46G位点，在亚洲亚组中，在隐性基因模型下，发现该位点与COPD的相关性有统计学意义(P=0.006，OR=0.58，95%CI 0.39~0.85)。对于C79G位点，在亚洲亚组中，在等位基因模型以及显性模型下，均发现该位点与COPD有相关性(等位基因模型：P=0.04，OR=1.29，95%CI 1.02~1.65；显性基因模型：P=0.03，OR=1.34，95%CI 1.02~1.76)。 结论：本研究发现在亚洲人群中ADRB2基因的A46G，C79G这2个位点与COPD易感性有关。
关键词：
β2肾上腺素能受体基因；慢性阻塞性肺疾病；单核苷酸多态性；荟萃分析
A Meta-analysis on investigating the association of ADRB2 genetic polymorphisms with chronic obstructive pulmonary disease
CorrespondingAuthor: XIE Weijian Email: 2316237956@qq.com
DOI: 10.3978/j.issn.2095-6959.2018.10.016
Abstract
Objective: To investigate the relationship between β2-adrenergic receptor (ADRB2) genetic polymorphisms (A46G and C79G) and chronic obstructive pulmonary disease (COPD). Methods: To find out all the case-control studies, we conducted a computer retrieval of Medline and Embase databases. The association between these two polymorphisms and COPD was examined through quantitative analysis by RevMan 5.0 software. The analysis included the calculation of the pooled odds ratios (ORs) as well as 95% confidence interval (CI), the evaluation of the between-study heterogeneity and the performance of sensitivity analysis. The Stata 12.0 software was performed to assess the publication bias. Results: Finally, 9 eligible articles involving 1 037 cases and 1 134 controls for A46G as well as 1 156 cases and 1 026 controls for C79G were collected. For all subjects, we found no statistical association between ADRB2 genetic polymorphisms and COPD risk. In the subgroup for Asian, a significant association was observed between A46G and COPD in the recessive model (P=0.006, OR=0.58, 95%CI 0.39–0.85), and between C79G and COPD in allele comparison and dominant model (allele comparison: P=0.04, OR=1.29, 95%CI 1.02–1.65; dominant model: P=0.03, OR=1.34, 95%CI 1.02–1.76). Conclusion: Our meta-analysis provided limited evidence for the genetic association of ADRB2 A46G and C79G polymorphisms with COPD risk in Asian.
Keywords：
β2-adrenergic receptor gene; chronic obstructive pulmonary disease; single nucleotide polymorphism; Meta-analysis