Objective: To observe the clinical efficacy of Qingjin Huatan Huoxue decoction in the treatment of patients on acute exacerbation of chronic obstructive pulmonary disease with phlegm-heat obstructing lung syndrome. Methods: A total of 100 patients were divided into a control group and a treatment group by random number table method, with 50 cases in each group. Patients in the control group received conventional western medicine treatment, while the treatment group received oral Qingjin Huatan Huoxue decoction on the basis of the control group treatment program. All patients were treated for 15 d. The clinical symptom scores of coughs, wheezing, expectoration and so on, total effective rate, inflammation index [white blood cell count (WBC), C-reactive protein (CRP), IL-6], arterial blood gas (PaO2, PaCO2) were compared between the two groups before and after treatment. Results: The total effective rate was 96.0% in the treatment group and 90.0% in the control group. The clinical effect of the treatment group was significantly better than that of the control group, and the difference was statistically significant (U=2.199, P<0.05). After treatment, the scores of symptom scores, inflammatory markers (WBC, CRP, N%, IL-6) and arterial blood gas (PaO2, PaCO2) in each group were statistically significant (P<0.05) compared with those before treatment. Meanwhile, the scores of symptoms, inflammation (WBC, CRP, N%, IL-6), arterial blood gas (PaO2, PaCO2) levels in the treatment group were also statistically significant (P<0.05) than the control group after treatment. Conclusion: Qingjin Huatan Huoxue decoction is effective in the treatment of patients with fever-dispelling lung type AECOPD. It has better clinical efficacy than western medicine alone.