Objective: To explore the clinical efficacy of automatic elastic line hemorrhoids ligation combined with submucosal injection for mild to moderate mixed hemorrhoids. Methods: A total of 120 patients with mild and moderate mixed hemorrhoids were selected as the research object. 60 patients with simple automatic elastic line hemorrhoid ligation were used as the control group, and 60 patients with submucous injection of automatic elastic line hemorrhoids were used as the experimental group, and the treatment effect of the two groups was observed. Results: The total effective rate of the experimental group was 100%, which was significantly higher than that of the control group (85%). After treatment, the treatment scores of the two groups were obviously improved, and after the treatment, the symptom scores of the patients in the experimental group were significantly lower than those of the control group, and the incidence of complications in the experimental group was 1.67%, which was significantly lower than that of the control group (13.33%), and the difference was statistically significant (P<0.05); there was no recurrence in the experimental group, and the recurrence rate in the control group was 1.67%. There was no significant difference between the two groups (P>0.05). Conclusion: Mixed hemorrhoid is a special disease of hemorrhoids. Operation is the main treatment method for this disease. The application of automatic elastic line hemorrhoid ligation with submucous injection has an clinical effects ideal, and it can effectively control the incidence and recurrence rate of complications.