比沙可啶作为肠道准备辅助药物的有效性
| 作者: |
1孙文荣,
1叶院宁,
1施慧,
1陆恒,
1汪芳裕
1 第二军医大学金陵医院，南京军区南京总医院消化内科，南京 210002 |
| 通讯: |
汪芳裕
Email: wangfy65@nju.edu.cn |
| DOI: | 10.3978/j.issn.2095-6959.2018.10.011 |
| 基金: | 国家自然科学基金 (81570506)。 |
摘要
目的：评估比沙可啶作为低剂量聚乙二醇(polyethylene glycol，PEG)肠道准备方案辅助药物的有效性和安全性。方法：纳入于第二军医大学金陵医院门诊行结肠镜检查的300例患者，按1:1随机分为2组，分别使用2 L PEG+10 mg比沙可啶(2L组)和3 L PEG(3L组)进行肠道准备。肠道准备质量依据Boston肠道准备评分量表(Boston Bowel Preparation Scale，BBPS)进行评估。主要观察指标为肠道准备合格率，次要观察指标为腺瘤检出率、不良反应发生率、患者的依从性、耐受性和复检意愿。 结果：2L组患者的肠道准备合格率(89.3%)与3L组(90.7%)相近(P>0.05)，两组的BBPS总评分、各肠段评分及腺瘤检出率的差异无统计学意义(P>0.05)。2L组恶心、呕吐的发生率明显低于3L组，患者的耐受性和依从性优于3L组，患者的复检意愿高于3L组(均P<0.05)。结论：2 L PEG+10 mg比沙可啶提高了患者的耐受性、依从性及复检意愿，且具有与3 L PEG相似的肠道准备质量。
关键词：
肠道准备；结肠镜；聚乙二醇；比沙可啶
Efficacy of bisacodyl as an adjunct for bowel preparation
CorrespondingAuthor: WANG Fangyu Email: wangfy65@nju.edu.cn
DOI: 10.3978/j.issn.2095-6959.2018.10.011
Foundation: This work was supported by the National Natural Science Foundation of China (81570506).
Abstract
Objective: To evaluate the efficacy and safety of bisacodyl as an adjunct for low-volume polyethylene glycol (PEG) bowel preparation. Methods: A total of 300 outpatients registered for colonoscopy were randomly divided into two groups according to 1:1, using 2 L PEG + 10 mg bisacodyl (2L group) and 3 L PEG (3L group) for bowel preparation. The bowel preparation quality was assessed by the Boston Bowel Preparation Scale (BBPS). The primary outcome was the rate of adequate bowel preparation, and the secondary outcomes were adenoma detection rate, adverse reaction rate, patient compliance, tolerance, and willingness to repeat bowel preparation. Results: The rate of adequate bowel preparation of the 2L group (89.3%) was similar to that of the 3L group (90.7%). There was no difference in the total BBPS score, the score of each intestinal segment and the adenoma detection rate between the two groups. The incidence of nausea and vomiting in 2L group was significantly lower than that in 3L group. The tolerance and compliance of patients in 2L group were better than those in 3L group. The willingness to repeat bowel preparation was higher than that of 3L group (P<0.05). Conclusion: Bowel preparation with 2 L PEG + 10 mg bisacodyl improves patient tolerance, compliance and willingness to repeat, and has a similar quality of bowel preparation as 3L PEG.
Keywords：
bowel preparation; colonoscopy; polyethylene glycol; bisacodyl