伴复杂病史及家族史的胃转移性乳腺小叶癌1 例并文献复习
作者: |
1马秋洁,
1吴建设,
1曹戬
1 中国中医科学院广安门医院南区病理科,北京 102618 |
通讯: |
马秋洁
Email: maqiujie777@126.com |
DOI: | 10.3978/j.issn.2095-6959.2018.06.037 |
摘要
胃的继发性肿瘤不常见,对于胃的转移性乳腺癌的临床特点、诊断及治疗尚缺乏全面系统的研究。本例患者乳腺小叶癌术后8年,双侧卵巢发现乳腺癌转移灶,但转移癌的激素受体表达和原发肿瘤差别较大;卵巢肿瘤术后发现与乳腺原发肿瘤免疫表型比较一致的胃内转移灶。患者有复杂的肿瘤家族史,基因检测未发现BRAC1,BRAC2及其他基因胚系致病变异。尚需积累大量资料,为乳腺癌消化道转移的患者提供科学诊疗方案。
关键词:
乳腺癌;胃肿瘤;转移癌;免疫组织化学
Gastric metastatic breast lobular carcinoma with complicated medical and family history: A case report and literature review
CorrespondingAuthor: MA Qiujie Email: maqiujie777@126.com
DOI: 10.3978/j.issn.2095-6959.2018.06.037
Abstract
Secondary tumors of the stomach are not common. There is no systematic and comprehensive research on the clinical characteristics, diagnosis and treatment of metastatic breast cancer. This patient underwent radical mastectomy for breast lobular carcinoma 8 years ago. Recently, bilateral ovarian metastasis was found; the metastasis of breast cancer was considered, but the immunophenotype was different from that of the primary breast tumor. After ovarian tumor surgery, metastatic carcinoma in the stomach was found to be in accordance with the immunophenotype of the primary breast tumor. The patient had a complex family history of tumor, and gene detection did not detect the pathogenic mutation of BRAC1, BRAC2 and other gene embryo lines. It is still necessary to analyze and summarize a large number of case datas to provide a scientific treatment for patients with digestive tract metastasis of breast cancer.
Keywords:
breast cancer; gastric neoplasm; metastatic carcinoma; immunohistochemistry