南京市雨花台区孕早期红细胞叶酸水平参考范围的建立
| 作者: |
1谢开鹏,
2白静,
2林萍,
3张金红,
4王向红,
3张爱君,
1郭锡熔,
1季晨博,
2丁慧
1 南京医科大学附属妇产医院医学研究中心，南京市妇幼保健院，南京 210004 2 南京市雨花台区妇幼保健所群体保健科，南京 210029 3 南京市雨花台区妇幼保健所妇女保健科，南京 210029 4 南京市雨花台区妇幼保健所检验科，南京 210029 |
| 通讯: |
丁慧
Email: 670135681@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.06.028 |
| 基金: | 国家 973 计划 (2013CB530604)，南京市医学科技发展项目 (YKK13223) |
摘要
目的：了解南京市雨花台区孕早期妇女红细胞叶酸水平，建立南京市雨花台区孕早期妇女红细胞叶酸水平参考范围。方法：选择2013年5月至2014年8月在南京市雨花台区妇幼保健中心正常体检的1 793例孕早期妇女作为研究对象，年龄20~40岁。应用化学发光免疫手段检测孕妇红细胞叶酸水平，建立南京市雨花台区红细胞叶酸参考范围，比较不同年龄段及不同季节红细胞叶酸水平的差异。结果：纳入的孕早期人群红细胞叶酸参考水平为748.13(384.71~1 322.38)ng/mL，有58例(3.23%)低于预防神经管畸形(neural tube defects，NTDs)的最低水平906 nmol/L。不同年龄段和不同季节的人群红细胞叶酸水平差异有统计学意义(均P<0.001)。在不同年龄段，红细胞叶酸水平随年龄增长而递增；在不同季节中，秋冬季红细胞叶酸水平低于预防NTDs最佳水平的比例相对较高(依次为6.00%和5.76%)。结论：南京市雨花台地区孕早期妇女红细胞叶酸低于预防NTDs最佳水平比例相对较低，在制订南京市雨花台区孕期妇女增补叶酸计划时，应结合年龄和季节因素给予孕妇补充不同水平的叶酸。
关键词：
孕早期；红细胞叶酸水平；参考范围
Establishment of reference range of red blood cell folate levels in first-trimester of pregnant women in the Yuhuatai area of Nanjing
CorrespondingAuthor: DING Hui Email: 670135681@qq.com
DOI: 10.3978/j.issn.2095-6959.2018.06.028
Foundation: This work was supported by the National Key Basic Research Program (2013CB530604) and the Medical Science and Technology Development Foundation of Nanjing (YKK13223), China
Abstract
Objective: To understand the red blood cell (RBC) folate levels in first-trimester of pregnant women in the Yuhuatai area of Nanjing and to establish reference range of folate levels in erythrocytes. Methods: A total of 1 793 pregnancy women aged 20~44 years old during first-trimester were recruited in Nanjing Yuhuatai maternity and child care center from May 2013 to August 2014. We measured RBC folate concentrations by chemiluminescence immune assay, established the reference range of RBC folate and analyzed the folate levels in difference age groups and seasons. Results: There were 58 subjects (3.23%) with RBC folate level of < 906 nmol/L, which was now accepted as the optimal folate concentration to minimize the occurrence of neural tube defects (NTDs). The levels of folate were significantly different in different age groups and seasons (all P<0.001). There was an increased tendency between age and folate levels. High proportion of women with RBC folate level of <906 nmol/L was observed in autumn (6.00%) and winter (5.76%). Conclusion: The proportion of women with RBC folate level of <906 nmol/L in the Yuhuatai area of Nanjing is low. It is reasonable to formulate the local folic acid supplementation policy considering the age and seasons factors.
Keywords：
first-trimester of pregnancy; red blood cell folate levels; reference range