左心室舒张功能不全患者左心房僵硬度指数与左心室舒张功能和 N 末端B 型利钠肽前体的相关性
| 作者: |
1张驰原,
1刘启明
1 长沙市中心医院心血管内科，长沙 410010 |
| 通讯: |
刘启明
Email: 971923273@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2018.06.019 |
摘要
目的：探究左心室舒张功能不全患者左心房僵硬度指数(left atrial stiffness index，LASI)与左心室舒张功能及血浆N末端B型利钠肽前体(N-terminal pro-brain natriuretic peptide，NT-proBNP)浓度的关系，明确其在左心室舒张功能不全方面的临床意义。方法：选取2015年8月至2016年2月在中南大学湘雅二医院经超声检查确诊的左心室舒张功能不全患者58例，分为左心室无肥厚组(30例)与左心室肥厚组(28例)，随机选取健康正常人30例为对照组，超声测量并计算所有入选组的二尖瓣瓣口舒张早期峰值血流速度/二尖瓣瓣口舒张中晚期峰值血流速度(E/A)、E/二尖瓣舒张早期峰值运动速度(E/é)、LASI值，同时检测两组的血浆NT-proBNP浓度，最后将测得的LASI分别与E/A，E/é及NT-proBNP作相关性分析。结果：血浆NT-proBNP浓度在对照组、左心室无肥厚组、左心室肥厚组组间差异无统计学意义(P>0.05)；左心室肥厚组、左心室无肥厚组E/A均低于对照组；E/é均高于对照组；左心室肥厚组E/é较左心室无肥厚组更高；左心室肥厚组、左心室无肥厚组LASI均高于对照组；左心室肥厚组LASI较左心室无肥厚组更高，差异均有统计学意义(均P<0.05)。LASI与E/é呈正相关(r=0.575，P=0.023)；LASI与E/A呈负相关(r=−0.481，P=0.021)；LASI与NT-proBNP不相关(r=0.078，P=0.472)。结论：LASI可反映左心室舒张功能不全患者左心室舒张功能。LASI与血浆NT-proBNP浓度无关。
关键词：
左心室舒张功能不全；左心房僵硬度指数；N末端B型利钠肽前体
Correlation between left atrial stiffness index and left ventricular diastolic function and N-terminal pro-brain natriuretic peptide in patients with left ventricular diastolic dysfunction
CorrespondingAuthor: LIU Qiming Email: 971923273@qq.com
DOI: 10.3978/j.issn.2095-6959.2018.06.019
Abstract
Objective: To investigate the relationship between left atrial stiffness index (LASI) and left ventricular diastolic function and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with left ventricular diastolic dysfunction and to evaluate the value of LASI in the term of patients with left ventricular diastolic dysfunction. Methods: Fifty-eight patients with left ventricular diastolic dysfunction diagnosed echocardiogram were divided into two groups by with (28 cases) or without (30 cases) left ventricular hypertrophy. Thirty normal people were chosen as an age-matched control group. The concentration of NT-proBNP was measured by immunofluorescence method. The E/A, E/é and LASI were detected by echocardiogram and calculated. The correlation between LASI and E/A and E/é was analyzed. Results: There concentration of NT-proBNP was no significant difference between patients with left ventricular diastolic dysfunction and in the control group (P>0.05). LASI both in left ventricular diastolic dysfunction with and without left ventricular hypertrophy were significantly higher than that in the control group; LASI in left ventricular diastolic dysfunction with left ventricular hypertrophy was significantly higher than that without left ventricular hypertrophy; E/é both in left ventricular diastolic dysfunction with and without left ventricular hypertrophy was significantly higher than that in the control group; E/é in left ventricular diastolic dysfunction with left ventricular hypertrophy was significantly higher than that without left ventricular hypertrophy; E/A both in left ventricular diastolic dysfunction with and without left ventricular hypertrophy were significantly lower than that in the control group, the differences were statistically significant (all P<0.05). LASI was positively related to E/é (r=0.575, P=0.023). LASI was negatively related to E/A (r=−0.481, P=0.021). LASI was not related to the concentration of NT-proBNP (r=0.078, P=0.472). Conclusion: LASI can reflect left ventricular diastolic function. There is no relationship between LASI and the concentration of NT-proBNP.
Keywords：
left ventricular diastolic dysfunction; left atrial stiffness index; N-terminal pro-brain natriuretic peptide