维生素D3——非糖尿病肾病慢性肾脏病合并糖尿病的预测因子
| 作者: |
1李宝来
1 内蒙古林业总医院肾内科，内蒙古 牙克石 022150 |
| 通讯: |
李宝来
Email: libaolai1026@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2017.01.001 |
摘要
目的：研究非糖尿病肾病慢性肾脏病(non-diabetes chronic kidney diseases，ND-CKD)3~5期患者合并糖尿病的相关因素，并用体内维生素D3水平来预测其风险。方法：对ND-CKD3~5期患者的糖尿病发生指标和维生素D3水平进行相关性分析，应用多项logistic回归分析，得出不同水平的维生素D3的ND-CKD合并糖尿病的概率值。结果：ND-CKD3~5期患者体内的维生素D3水平和餐后2 h血糖有负相关性(r=–0.430，P=2.07×10–5)；该人群体内维生素D3在0~99.9，100.0~199.9，200.0~299.9 nmol/L三个水平合并糖尿病的概率分别为0.393，0.227，0.154。结论：维生素D3作为ND-CKD合并糖尿病的预测因子，有一定的临床意义。
关键词：
慢性肾脏病
糖尿病
维生素D3
Vitamin D3—a prognostic factor for non-diabetes chronic kidney diseases
CorrespondingAuthor: LI Baolai Email: libaolai1026@163.com
DOI: 10.3978/j.issn.2095-6959.2017.01.001
Abstract
Objective: To identify the relevant factor of non-diabetes-chronic kidney disease (ND-CKD) 3—5 phrase and apply vitamin D3 to predict its risk. Methods: A correlation analysis of vitamin D3 and parameters of diabetic occurrence were made and a logistic regression analysis was applied to work out probability value of ND-CKD in different vitamin D3 levels between occurrence indicators of patient in ND-CKD 3—5 phrase and vitamin D3 level. Results: There was a negative correlation with statistically significant difference (correlation coefficient was −0.430, P=2.07×10–5) between vitamin D3 and serum glucose 2 h after oral glucose tolerance in ND-CKD patients. The rate of diabetic occurrence in ND-CKD patients with three different vitamin D3 levels (0—99.9, 100.0—199.9, 200.0—299.9 nmol/L) were estimated respectively as 0.393, 0.227 and 0.154 due to logistic analytic results. Conclusion: There is clinical significance for vitamin D3 to be a prognostic factor for ND-CKD.