Objective: To investigate the clinical application effects of responsibility contract work system in the intensive intravenous infusion nursing quality management. Methods: A total of 112 cases of critical ill patients in the surgery of our hospital from April 2012 to April 2014 were divided into the control group and research group randomly, each group contained 56 cases. The patients of the control group were given the conventional intravenous infusion nursing intervention, and the patients of research group were given responsibility contract work system in the infusion. Results: The single-day infusion (1.81±0.68) h, and infusion error rate (14.29%) in research group were statistically lower than those in the control group (P<0.05), and there was a statistically higher single puncture success rate(98.21%) than that (91.07%) in the control group (P<0.05). Furthermore, the nursing quality score of the research group was significantly higher than that of the control group (P<0.05). Conclusion: The implementation of responsibility contract work system in the critical intensive intravenous infusion nursing quality management can significantly improve the clinical service quality, avoid adverse events, and provide basic protection for good nurse-patients relationship.