脊索瘤2例临床病理特征并文献复习
| 作者: |
1王海艳,
1吴永芳,
1许春伟,
1张博,
1邵云,
1王怀涛,
1李晓兵,
1张凤霞
1 军事医学科学院附属医院病理科，北京 100071 |
| 通讯: |
张博
Email: zenwo@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.06.024 |
摘要
目的：探讨脊索瘤的临床病理特征、诊断及鉴别诊断、治疗和预后。方法：对本研究组的2例脊索瘤的临床病理特征和免疫组织化学特点进行分析，并结合相关文献复习。结果：脊索瘤瘤细胞呈分叶状结构，细胞散在或呈条索及小巢状，液滴状细胞体积较大，胞浆中含大小不等的空泡；另一种体积小呈星芒状，且胞浆内无空泡。免疫组织化学显示，1例瘤细胞CK、EMA、S-100、Vimentin阳性表达，另1例CK、EMA、Vimentin阳性表达，而S-100阴性。结论：脊索瘤发病率低，但根据其常见的发病部位及特征性的组织形态，结合免疫组织化学方法，有助于其诊断及鉴别诊断。
关键词：
脊索瘤
诊断
鉴别诊断
临床病理
Two case of chordoma with clinicopathological features of and literature review
CorrespondingAuthor: ZHANG Bo Email: zenwo@qq.com
DOI: 10.3978/j.issn.2095-6959.2015.06.024
Abstract
Objective: To investigate and discuss the clinicopathological features diagnosis and differential diagnosis, treatment and prognosis of chordoma. Methods: By analyzing the features of clinicopathological with immunohistochemical of 2 cases, and combining together the review of the literatures. Results: A total of 2 cases showed lobulated architecture, and the cells diffused distribution, bridge-like or growth with nests. The larger tumor cells were physaliphorous have inequality vacuoles of size in cytoplasm; the other small satellite-like cells have no vacuoles. Immunohistochemically, 1 case showed positive immunostaining for CK, EMA, S-100, Vimentin; the other showed positive immunostaining for CK, EMA, Vimentin, while negative for S-100. Conclusion: Chordomas have a low incidence, but their frequent position of invasion and their typical histology shape, to combine together immunohistochemistry methods will make for diagnosis and differential diagnosis possible.