文章摘要

表皮生长因子受体与胃癌的研究进展

作者: 1朱欢, 1邓玲, 2伍尤华, 3苏琦
1 南华大学附属第一医院肿瘤科，湖南 衡阳 421001
2 湖南省胃癌研究中心，湖南 衡阳 421001
3 南华大学肿瘤研究所，湖南 衡阳 421001
通讯: 伍尤华 Email: 330270372@qq.com
苏琦 Email: suqi1945@163.com
DOI: 10.3978/j.issn.2095-6959.2016.12.029
基金: 国家自然科学基金, 81374013 湖南省卫计委科研重点课题, A2015-2

摘要

胃癌的发生与发展机制十分复杂，涉及多种细胞病理改变。表皮生长因子受体(epidermal growth factor receptor，EGFR)及其参与的信号转导通路在胃癌的发生发展中起着重要的作用。近年来，发现多数肿瘤对放化疗存在的耐药性，因此在肿瘤的基因水平寻找诊断指标以及靶向治疗，已经成为近年来研究热点之一。本文综述表皮生长因子与胃癌的研究进展。
关键词： 人表皮生长因子 胃癌 信号通路

Research progress on epidermal growth factor receptor and gastric cancer

Authors: 1ZHU Huan, 1DENG Ling, 2WU Youhua, 3SU Qi
1 Department of Oncology, First Affiliated Hospital of University of South China, Hengyang Hunan 421001
2 Center for Gastric Cancer Research of Hunan Province, Hengyang Hunan 421001
3 Cancer Research Institute, University of South China, Hengyang Hunan 421001, China

CorrespondingAuthor: WU Youhua Email: 330270372@qq.com

DOI: 10.3978/j.issn.2095-6959.2016.12.029

Abstract

The mechanism of occurrence and development in gastric cancer is very complex, involving a variety of cell pathological changes. Epidermal growth factor receptor (EGFR) and its mediating in signal transduction pathways play an important role in the development of gastric cancer. In recent years, with the resistance to radiotherapy and chemotherapy of the most tumors, searching diagnostic indicators and target therapy for tumors in gene level has become one of hot spots of research. This article reviews the research progress of EGFR that is correlation with gastric cancer.

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