ApoE4在阿尔茨海默病中的研究进展
| 作者: |
1杨小惠,
1吴芹,
1石京山
1 遵义医学院基础药理省部共建教育部重点实验室暨药理学教研室，贵州 遵义 563000 |
| 通讯: |
石京山
Email: shijs@zmc.edu.cn |
| DOI: | 10.3978/j.issn.2095-6959.2017.03.031 |
| 基金: | 国家自然科学基金, 81473201 |
摘要
载脂蛋白E(apolipoprotein E，ApoE)是一种脂质转运蛋白，在中枢神经系统的神经元中丰富表达，而ApoE4是其中的一种亚型。研究表明ApoE4是阿尔茨海默病(Alzheimer’s disease，AD)的危险因素之一，会提高AD的发生率及降低其发病年龄。深入研究ApoE4的结构特性及在AD中的作用机制，有望使其成为诊治AD的靶点。
关键词：
载脂蛋白E4
阿尔茨海默病
治疗靶点
Research progress of apolipoprotein E4 in Alzheimer’s disease
CorrespondingAuthor: SHI Jingshan Email: shijs@zmc.edu.cn
DOI: 10.3978/j.issn.2095-6959.2017.03.031
Abstract
Apolipoprotein E (ApoE), as a lipid transporter, is abundantly expressed in the neurons of the central nervous system. APOE4, the major known genetic risk factor for Alzheimer’s disease (AD), increases the occurrence and lowers the age of onset of AD. Understanding structural properties of ApoE4 is important for determining the development of therapeutic strategies in the treatment of various diseases and advancing their effects. ApoE4 may be a target for diagnosis, risk assessment, prevention and treatment of AD.