Objective: To explore the clinical effect and safety of Simotang oral solution on gynecological laparotomy postoperative gastrointestinal motor function. Methods: A randomized, double-blind, placebo-controlled, prospective study was designed, selected 79 cases of gynecologic laparotomy in the treatment group and 69 cases in the placebo control group. On the first day after surgery, the treatment group were treated with Simotang oral solution, and placebo control group with simulated Simotang oral solution. Recorded gastroinstestinal motility function, quality of life scores, safety detection, adverse reaction and complications, etc. The clinical data of the two groups were compared and statistically analysed. Results: Compared with placebo control group, the time of the first bowel sound’s recovery, first passage of flatus and first defecation in the treatment group were decreased 9, 7 and 8 h, respectively (P<0.01) in Simotang treatment group. Simotang treatment group was also better than placebo control group in the promotion of gastrointestinal movement. Quality of life scores of the fourth day after operation in the treatment group was significantly higher than control group. However, there was no obvious difference in adverse effect and complications between two groups. Conclusion: Simotang oral solution can effectively promote gynecological laparotomy postoperative recovery of gastrointestinal motor function, reduce the degree of postoperative abdominal distension and improve the quality life of patients, without significant clinical side effects.