Transient receptor potential melastatin 7 (TRPM7) is a non-selective cation channel, which is found in recent years. It has the unique dual function of ion channel and protein kinase domain. The study found that TRPM7 is widely distributed in various organs and tissues. TRPM7 involves in a variety of physiological processes by regulating the cell membrane potential, regulating the intracellular and extracellular ion homeostasis, affecting the way of intracellular signaling pathways. It was found that TRPM7 plays an important role in regulating cell homeostasis, cell growth, proliferation, growth, and all kinds of inflammatory responses. The purpose of this paper is to explain the function and mechanism of TRPM7, and to explore the important pathological and physiological significance of TRPM7 in kidney disease, and to find the possible treatment method for the treatment of kidney disease.