肺血管内皮细胞分泌功能的改变与急性肺损伤/急性呼吸窘迫综合征
| 作者: |
1江秀芳,
2陈泉,
1王德明
1 南华大学附属第二医院麻醉科， 湖南 衡阳 421001 2 娄底市中心医院麻醉科，湖南 娄底 417600 |
| 通讯: |
王德明
Email: wdm1998@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2016.12.033 |
| 基金: | 国家自然科学基金应急管理项目, 81641152 国家自然科学基金青年科学基金项目, 81301625 湖南省科学计划项目, 2013FJ6006 |
摘要
急性肺损伤(acute lung injury，ALI)/急性呼吸窘迫综合征(acute respiratory distress syndrome，ARDS)是临床上常见的急危重症，病死率高达25%~45%，治疗上主要限于器官功能与全身支持治疗，尤其是呼吸支持治疗，“等待”肺损伤的缓解。在ARDS发病机制中肺血管内皮细胞(pulmonary vascular endothelial cell，PVEC)既是受损的主要靶细胞，更是活跃的炎症和效应细胞，血管内皮细胞(vascular endothelial cell，VEC)的激活和损伤程度与ARDS预后密切相关。本文将主要阐述ALI/ARDS发病机制中PVEC部分分泌功能的改变。
关键词：
肺血管内皮细胞
急性肺损伤/急性呼吸窘迫综合征
分泌功能
Secreting function of pulmonary vessel endothelial cells with acute lung injury/acute respiratory distress syndrome
CorrespondingAuthor: WANG Deming Email: wdm1998@163.com
DOI: 10.3978/j.issn.2095-6959.2016.12.033
Abstract
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common clinical emergencies and severe disease. The mortality rate is as high as 25%—45%. The mainly treatment is limited to organ function and systemic supportive care treatment, especially respiratory support treatment, “waiting” to alleviate the lung injury. In the pathogenesis of ARDS, the pulmonary vascular endothelial cells (PVEC) are not only the mainly target cells to be damaged, but also the active inflammatory cells and effector cells. And the degree of activation and damage of vascular endothelial cells (VEC) is closely related with the prognosis of ARDS. In this paper, we will focus on the changes of PVEC partial secretion function in the pathogenesis of ALI/ARDS.