文章摘要

TRPM7与乳腺癌的研究进展

作者: 1王欣玮, 2张莉莉, 1汤依群
1 中国药科大学基础医学与临床药学学院，南京 210009
2 江苏省肿瘤医院内科，南京 210009
通讯: 汤依群 Email: tyq@cpu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2017.03.028
基金: 江苏省卫生厅科研项目, H201327

摘要

瞬时受体电位(transient receptor potential，TRP)通道是一种非选择性阳离子通道超级家族。作为TRPM亚家族的一员，TRPM7因其独特的丝氨酸/苏氨酸激酶结构、广泛的分布以及多样的生理功能而引起了关注。众多研究结果表明：TRPM7通道的表达或功能异常与乳腺癌的发生及发展密切相关。目前，转移性乳腺癌不可被治愈，是导致乳腺癌患者死亡的主要原因。
关键词： 瞬时电位受体通道 TRPM7 乳腺癌 转移 侵袭

Recent progress of TRPM7 and breast cancer

Authors: 1WANG Xinwei, 2ZHANG Lili, 1TANG Yiqun
1 School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009
2 Department of Internal Medicine, Jiangsu Provincial Tumor Hospital, Nanjing 210009, China

CorrespondingAuthor: TANG Yiqun Email: tyq@cpu.edu.cn

DOI: 10.3978/j.issn.2095-6959.2017.03.028

Abstract

Transient receptor potential (TRP) superfamily are non-selective cation channels. As a member of TRPM subfamily, TRPM7 has received much attention for its unique serine/threonine kinase domain, ubiquitous distribution and various physiological functions. Numerous studies have demonstrated that abnormal expression and function of TRPM7 channels are closely related to the formation and growth of breast cancer. So far, metastatic breast cancer cannot be cured and is the leading cause of mortality among patients with breast cancer.

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