Objective: To evaluate the application effects of health education pathway in patients with hyperthyroidism. Methods: 156 cases of patients with hyperthyroidism in our hospital from August 2015 to February 2016 were recruited, and were divided into research group (routine nursing + health education pathway) and control group (routine nursing); nursing satisfaction, health knowledge level, medication compliance, clinical therapeutic effects between two group were compared. Results: Compliance, degree of psychological comfort, degree of convenience and average satisfaction in research group were higher than that in control group, the difference was statistically significant (P<0.05). There was no significant difference between the two groups before the intervention in health knowledge level and medication compliance (P>0.05). Health knowledge level and medication compliance of research group were higher than that of control group, the difference was statistically significant (P<0.05). Time of symptom disappearance and time of index return to normal in research group were shorter than that in control group, and thyroid volume was smaller than control group, the difference was statistically significant (P<0.05). Conclusion: Health education pathway could effectively improve the health knowledge level and medication compliance, and then promote the improvement of nursing satisfaction and clinical effects.