Objective: To analysis the curative effect of endoscopy low-temperature plasma radiofrequency ablation and normal laryngeal crack treatment in early glottis type of throat cancer. Methods: 100 cases of early glottic cancer from February 2011 to February 2014 in our hospital were analyzed and divided into control group (50 cases) and treatment group (50 cases) due to the draw method. The control group was treated with normal larynx crack treatment; the treatment group was carried out by endoscopic low-temperature plasma radiofrequency ablation. Observed the situation of surgery of two groups, voice changes, vocal mucosa recovery, complications and recurrence rate were compared. Results: The intraoperative blood loss, operative time, length of hospital stay of treatment group were better than those of control group (P<0.05); 1 month after operation, the speech situation (fundamental frequency perturbation, amplitude perturbation, harmonic noise ratio) of the treatment group was 1.15%±0.12%, 2.61%±0.33%, (22.30±3.74) dB, which were better than those of the control group [1.27%±0.16%, 4.29%±0.38%, (20.12±3.22) dB], the difference between two groups was significant (P<0.05); the total complication rate (6.00%, 3/50) of treatment group is lower than that of the control group (20.00%, 10/50), the difference was significant (P<0.05); vocal mucosa smooth rate (94.00%, 47/50) of treatment group was higher than that of the control group (60.00%, 30/50; P<0.05); the recurrence of two groups had no difference (P>0.05). Conclusion: The endoscopic low-temperature plasma radiofrequency ablation for treating early glottis cancer can significantly improve voice situation of patient, at the same time, it has less postoperative complications and lower recurrence rate, which is worth promoting.