Objective: To investigate the nursing methods of skin mucosa for toxic epidermal necrolysis (TEN) epidermolysis and exfoliative patients in large area. Methods: Nine TEN hospitalized patients put under quarantine, with actively support treatment, were applied with the combination of nano-silver ion dressing and sterile pad to covering the wound. Intensive care and a strict watch were supported by the nursing experts in intensive care wards. Results: All 9 cases don’t get any skin mucosa infection, and 8 of them are discharged from hospital with good recovery of their skins and no scars or pigmentation. But the ninth one died from multiple organ failure. Conclusion: Based on the reasonable treatment, careful nursing was the key measures to increase survival of patients with TEN, reduce the rate of wound infection and scars or pigmentation occurrence.