复合性肺小细胞癌合并皮肤神经纤维瘤临床病理分析并文献复习
| 作者: |
1徐建平,
1赵洁婷,
2许春伟,
3陈燕坪
1 安徽省胸科医院病理科，合肥 230032 2 军事医学科学院附属医院病理科，北京 100071 3 福建医科大学教学医院福建省肿瘤医院病理科，福州 350014 |
| 通讯: |
徐建平
Email: xjpxkbl@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2016.08.037 |
| 基金: | 国家临床重点专科建设项目, 2013 军事医学科学院附属医院创新科研基金项目, ZH-2014-10 福建省自然基金青年人才创新项目, 2014J05085 福建省卫生厅青年创新课题, 2014-1-15 |
摘要
目的：探讨复合性肺小细胞癌合并皮肤神经纤维瘤的临床病理学特点、诊断要点及分子病理特点。方法：对1例复合性肺小细胞癌合并皮肤神经纤维瘤进行临床资料、病理形态学及免疫组织化学观察和分子病理检测，并结合文献对其进行探讨。结果：复合性肺小细胞癌镜下肿瘤细胞小，胞浆少或缺乏。细胞核呈短梭形、圆形或卵圆形，核染色质细颗粒状，核仁缺乏。在小细胞癌中或周边见腺癌及少量高分化鳞状细胞癌成份。皮肤神经纤维瘤镜下真皮层内纤维组织增生伴玻璃样变，散在较多粘液样变的结节。结论：复合性肺小细胞癌合并皮肤神经纤维瘤发生率低，预后差，形态学对本病的诊断具有重要价值。系统治疗方案有待临床进一步研究。
关键词：
复合性
小细胞癌
神经纤维瘤
诊断
免疫组织化学
Clinicopathologic analyses of combined small cell lung cancer with skin neurofibroma and review of the literature
CorrespondingAuthor: XU Jianping Email: xjpxkbl@163.com
DOI: 10.3978/j.issn.2095-6959.2016.08.037
Abstract
Objective: To investigate the characteristics of clinicopathology and diagnostic criteria about combined small cell lung cancer (CSCLC) with skin neurofibroma. Methods: Retrospectively analyzed the features of clinicopathology, immunohistochemistry and molecular pathology detection of a case of CSCLC with skin neurofibroma, and combining together the review of the literatures. Results: Under light microscope, CSCLC tumor cell body was small, and less or lack of cytoplasm, the nuclei was short spindle, round or ovoid, and nuclear chromatin tiny granular and lack nucleoli, and adenocarcinoma and few of high differentiated squamous cell carcinoma could be seen in and around small cell cancer. The microscopic of skin neurofibroma fibrous tissue hyperplasia in cuticle had hyalinization with more myxoid nodules. Conclusion: CSCLC with skin neurofibroma incidence is low and prognosis is poor, morphology and immunohistochemical characteristics have an important value to the diagnosis. System therapy remains to be further clinical study.