Objective: To explore the effect of group activities on depression and self-efficacy of patients with cervical cancer. Methods: 60 cervical cancer hospitalized patients who were treated in department of gynaecology of our hospital from January to June in 2014 were selected as the research object. All the patients were randomly divided into control group and observation group. There were 30 patients in each group. The control group was given routine discharge nursing instruction, the observation group were increased the activities of the group activity continuity nursing content on the basis of the routine discharge nursing instruction. After 3 months of intervention, the data from Exercise of Self-Care Agency Scale (ESCA), Self-Rating Depression Scale (SDS) and Self-test on Remark of Health Measuring Scale (SRHMS) were collected for statistical analysis of comparison. Results: After 3 months of care test, the SDS score in the observation group (40.72±6.39) was significantly lower than that in the control group (45.67±10.56), the scores of physiological, psychological and social dimensions of the three self-rated health in self-rated health and also total score were significantly higher than that in the intervention group, after the intervention for 30, 60, and 90 d, self-efficacy score (16.53±1.23, 19.98±1.42, 29.99±2.09) was significantly higher than those in the control group (13.76±1.01, 17.01±1.04, 20.02±1.31) (all P value <0.05), the difference was statistically significant. Conclusion: The group active nursing care can significantly improve the self-efficacy of patients with cervical cancer, effectively relieve the psychological pressure of the patients and reduce the generation of depression.