文章摘要

伴CSF3RT618I突变的慢性粒单核细胞白血病1例并文献复习

作者: 1王华, 1王志永, 1刘芳, 1辛春红, 1衣文婷, 1景瑞, 1尚应辉, 1董於坪, 2冯四洲
1 滨州医学院烟台附属医院，山东 烟台 264100
2 中国医学科学院北京协和医学院血液学研究所血液病医院，天津 300020
通讯: 王志永 Email: wzy1wzy@163.com
冯四洲 Email: sizhoufeng@medmail.com.cn
DOI: 10.3978/j.issn.2095-6959.2016.09.041
基金: 山东省自然科学基金, ZR2013HL001 天津市应用基础与前沿技术研究计划, 14JCZDJC33000 滨州医学院科研启动基金, BY2012KYQD02

摘要

目的：提高对伴CSF3RT618I突变的慢性粒单核细胞白血病(chronic myelomonocytic leukemia，CMML)的认识。方法：分析1例伴CSF3RT618I突变的CMML，结合文献复习讨论。结果：我们首次在CMML中报道CSF3RT618I突变。CSF3R突变的患者预后较差，酪氨酸激酶抑制剂能否改善其预后尚不清楚。结论：CSF3RT618I突变对CMML患者的预后影响还需要进一步临床研究来确定。
关键词： 慢性粒单核细胞白血病 CSF3R突变 酪氨酸激酶抑制剂

A case report of chronic myelomonocytic leukemia with CSF3RT618I mutation

Authors: 1WANG Hua, 1WANG Zhiyong, 1LIU Fang, 1XIN Chunhong, 1YI Wenting, 1JING Rui, 1SHANG Yinghui, 1DONG Yuping, 2FENG Sizhou
1 Department of Hematology, Yantai-Affiliated Hospital of Binzhou Medical University, Yantai Shandong 264100
2 Institute of Hematology & Blood Diseases Hospita, CAMS & PUMC, Tianjin 300020, China

CorrespondingAuthor: WANG Zhiyong Email: wzy1wzy@163.com

DOI: 10.3978/j.issn.2095-6959.2016.09.041

Abstract

Objective: To raise awareness of chronic myelomonocytic leukemia (CMML) with CSF3RT618I mutation. Methods: Analysis of a case of CMML with CSF3RT618I mutation, combined with literature review. Results: We first reported the CSF3RT618I mutation in CMML. The overall survival of patients with CSF3R mutations was low. The prognosis of the patients with tyrosine kinase inhibitors was not clear. Conclusion: The significance of CSF3RT618I mutation in CMML patients needs further clinical study.

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