Objective: To analyze the importance of hemodialysis combined with hemoperfusion, and discuss the efficacy on the treatment of phosphorus and calcium metabolism disorder in the patients of maintenancing hemodialysis. Methods: All of the patients treated with maintenancing hemodialysis in our hospital during 2015 were selected. A summary of 100 patients with chronic renal failure were chosen and randomly classified into the control group (n=50) and the experimental group (n=50). The control group were treated with hemodialysis, While experimental group were treated with hemodialysis combined with hemoperfusion. The serum concentration of BUN, Scr, complement C3, β2-MG, P, Ca and P product, iPTH, 1,25(OH)-D3, Alb, TC, Hb, RBC between the two groups were compared. Results: BUN, Scr, complement C3, β2-MG in two groups were improved significantly, while no statistical difference were found between the two groups; The indicators of phosphorus and calcium metabolism in experimental group at post-therapy became better than that in pre-therapy and in post-therapy of the control group. The indicators of nutritional status in experimental group at 3, 4 months after therapy were better than that of pre-therapy and the control group. There was no significant difference in the nutritional status of the control group. Conclusion: The hemodialysis combined with hemoperfusion can help flush out toxins and correct the disorder of calcium and phosphorus metabolism and improve the nutritional status, it’s worthy of clinical promotion.