This paper reviews the research progress of prevention and treatment of vitamin D in vascular calcification. We review the latest research about related domestic and overseas literature about vitamin D resistant vascular calcification. Basic experiments and clinical observations showed that vitamin D plays an important regulation role in vascular calcification. At present, the main researches focus on vitamin D suppressing the phenotype transformation of vascular smooth muscle cell, the main problem is the role of vitamin D in the regulation of vascular calcification of vascular smooth muscle cell phenotype, and more researches are needed to verify its role in the mechanism of vascular protection.