Objective: To research the clinical application effects of special nursing intervention in families of patients with advanced cancer palliative care. Methods: From March 2014 to June 2015, 101 cases with advanced cancer and 101 cases of family members were selected as the research objects. According to the order of treatment, they were divided into two groups. The control group had 52 cases, they were treated with palliative care, and the observation group had 49 cases, on the basis of palliative care in the control group, the special nursing intervention was carried out to the families of the patients in the observation group. Observed and analyzed the Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS) score in two groups of patients. Analyzed and compared anxiety and depression index before and after the intervention, compared the functional score of the QLQ-C30 scale after the intervention in two groups. Results: The SAS, SDS score of the families in the observation group were significantly lower than those in the control group (P<0.05). Compared the anxiety and depression index of the two groups of patients before and after the intervention, there is no significant difference between the two groups of patients before the intervention (P>0.05); but the index in the observation group was significantly lower than that in the control group after the intervention (P<0.05). The functional score of each item in the QLQ-C30 scale in the observation group was significantly higher than that in the control group (P<0.05). Conclusion: The effect of the special nursing intervention for patients’ families with advanced palliative care in the treatment of patients with advanced cancer is significant. The special nursing intervention for patients’ families can not only alleviate the anxiety and depression of patients’ families, but also affect the patients’ mood and improve the quality of life. It is worthy of clinical application.