Objective: To investigate the short-term effect of butylphthalide joint atorvastatin treatment on blood lipid levels of very elderly patients with cerebral infarction. Methods: The clinical data of 200 cerebral infarction patients (≥80 years old) undergoing drug therapies systematically were reviewed. Ninety eight cases in the statins group were treated with atorvastatin and antiplatelet drugs, 102 cases in the butylphthalide plus statins group were administrated by butylphthalide plus atorvastatin and antiplatelet drugs. The level of lipid biochemical parameters of each case pre- and post-treatment in above 2 groups was assayed. The short-term efficacy of butylphthalide plus atorvastatin on improving blood lipid levels of elderly with ischemic stroke was evaluated. Results: After 1 week systematic medication therapy, the levels of total cholesterol (TC) and low-density lipoprotein (LDL) in statins group decreased markedly (P<0.05), while the levels of triglycerides (TG), high-density lipoprotein (HDL) and lipoprotein (a) [Lp(a)] in this group had no significant change (P>0.05). For butylphthalide plus statins group, the levels of TG, TC and LDL had been decreased significantly (P<0.05), both HDL and Lp(a) had no significant difference compared with those of pre-treatment (P>0.05). Furthermore, the decrease extents of TG, TC and LDL in butylphthalide plus statins group were more significantly than those in statins group (P<0.05). Conclusion: Short-term therapy by butylphthalide plus atorvastatin can significantly improve the levels of TG, TC and LDL of very elderly patients with cerebral infarction, but no effect on HDL and Lp(a) levels.