恶性胸膜间皮瘤13例病理学报道及分析
| 作者: |
1李莘,
1王咏梅,
1杨鸿春
1 天津市海河医院病理科，天津市呼吸疾病研究所，天津 300350 |
| 通讯: |
李莘
Email: x_li2012@hotmail.com |
| DOI: | 10.3978/j.issn.2095-6959.2016.06.013 |
摘要
目的：探讨恶性胸膜间皮瘤的临床及病理学特点。方法：对天津市海河医院13例恶性胸膜间皮瘤患者的临床资料和病理学特征进行回顾性分析。结果：13例患者男性为主(69.2%)，中位年龄55岁，主要症状为胸闷(76.7%)，放射学主要表现为胸腔积液(69.2%)，7例(53.8%)确诊通过胸腔镜获得标本。病理表现上皮样型12例，肉瘤样型1例；免疫组织化学染色calretinin及D2-40阳性率较高(100%、76.7%)，CEA及TTF-1阳性率均为0。结论：恶性胸膜间皮瘤恶性程度高，应尽早行胸腔镜检查；除常规染色外，免疫组化染色可帮助鉴别诊断。
关键词：
恶性间皮瘤
胸膜
病理特点
D2-40
calretinin
Pathologic and clinical analysis of 13 cases with malignant pleural mesothelioma
CorrespondingAuthor: LI Xin Email: x_li2012@hotmail.com
DOI: 10.3978/j.issn.2095-6959.2016.06.013
Abstract
Objective: To discuss the clinicopathological features of malignant pleural mesothelioma. Methods: Analyzed 13 cases of malignant pleural mesothelioma of Tianjin Haihe Hospital and reviewed the relevant literatures. Results: Among the 13 cases, male was predominant (69.2%) and the median age was 55 years. The major clinical feature was chest distress (76.7%) and radiographic manifestation was pleural effusion (69.2%). Thoracoscopy was the main diagnosis method (53.8%). It concluded 12 cases with epithelioid type and 1 case with sarcomatoid type. The positive rates of calretinin and D2-40 were high (100%, 76.7%, respectively), and it was 0 in CEA and D2-40. Conclusion: Malignant pleural mesothelioma is fatal, so thoracoscopy should be applied immediately. Immunohistochemistry can help differentiate malignant pleural mesothelioma from other neoplasms.