Objective: To investigate the perioperative nursing methods on AIDS complicated with acute abdomen diseases. Methods: 42 cases of AIDS complicated with acute abdomen diseases from July 2012 to July 2015 were studied, the clinical features of patients and nursing treatment were analyzed. Results: 38 cases were healed without nosocomial infection and other serious complications by fast track nursing treatment (preoperative psychological intervention; avoid gastric tube, urine tube placement; reduce intraoperative drainage tube indwelling, intraoperative fluid control, temperature control, accelerate postoperative gastrointestinal function, rehabilitate pulmonary function, pain management, postoperative incision management, early removal of pipeline). Four cases with severe immune function defects suffered uncontrollable abdominal postoperative infection and multiple organ failure which led to death. Conclusion: Fast track nursing can prevent postoperative complications, reduce perioperative mortality and promote the fast-tract recovery on patients with AIDS complicated with acute abdomen diseases.