Objective: To analyze the incidence, predictors, clinical characteristics and prognosis of tamponade occurred in RFCA. Methods: The characteristics, clinical manifestations, diagnosis, treatment and prognosis were retrospectively analyzed in 21 (0.33%) patients who suffered from tamponade. Results: Incidences of tamponade for ablation of AF, ventricular arrhythmias (Vas) decreased over time with the extending learning curve of doctor. Incidence rate of tamponade in female was significantly higher than in male (5.4‰ vs. 1.2‰, P<0.05), especially for Vas ablation (9.0‰ vs. 1.2‰, P<0.05). Advanced age was significantly associated with tamponade, especially for Vas ablation (P<0.05). The first and easy-to-observe sign which indicated tamponade is accelerated heart rate and decrease in blood pressure. The average amount of bleeding in tamponade patients was (297.6±270.7) mL, which is higher in patients who undergoing surgical repair, (1 570.0±720.5) mL (P<0.05). Conclusion: Female, advanced age and learning curve were all related with tamponade in ablation, which should be observed carefully by clinical manifestations and X-ray examination and be timely treated.