文章摘要

细胞焦亡：程序性死亡研究新热点

作者: 1刘岳衡, 2王慧
1 中南大学湘雅二医院精神卫生研究所，长沙 410011
2 中南大学基础医学院人体解剖与神经生物学系，长沙 410013
通讯: 王慧 Email: wanghui2008@csu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2016.07.022
基金: 高校基本科研业务费重点项目, 2010QZZD022

摘要

细胞焦亡(Pyroptosis)是一种以促炎性为特点的细胞程序性死亡方式，分为依赖半胱氨酸蛋白酶-1(Caspase-1)的经典细胞焦亡途径和依赖半胱氨酸蛋白酶-4/5/11(Caspase-4/5/11)的非经典细胞焦亡途径。研究表明细胞焦亡广泛参与到多种疾病的发生发展中。最近研究人员发现GSDMD和Pannexin-1可能是介导细胞焦亡的关键物质，但具体机制和相互关系仍有待进一步深入研究。
关键词： 细胞焦亡 炎性半胱氨酸蛋白酶 GSDMD Pannexin-1

Pyroptosis: a new hotspot in the programmed cell death

Authors: 1LIU Yueheng, 2WANG Hui
1 Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha 410011
2 Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha 410013, China

CorrespondingAuthor: WANG Hui Email: wanghui2008@csu.edu.cn

DOI: 10.3978/j.issn.2095-6959.2016.07.022

Abstract

Pyroptosis is a form of programmed cell death mediated by inflammatory caspases. Pyroptosis includes canonical pyroptosis depending on caspase-1 activation and uncanonical pyroptosis depending on caspase-4/5/11 activation. Recently it is reported that pyroptosis plays a crucial role in a variety of diseases. Studies have shown that GSDMD, Pannexin-1 and P2X7 might be the key substrates for pyroptosis. But the process of pyroptosis is very complex and the detailed mechanism in pyroptosis requires further studies.

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