文章摘要

中枢神经系统损伤疾病的坏死性凋亡机制研究进展

作者: 1杨海玉, 2刘勇
1 江西省人民医院临床医学研究所，南昌 330006
2 江西省人民医院病理科，南昌 330006
通讯: 刘勇 Email: jxpathology@126.com
DOI: 10.3978/j.issn.2095-6959.2016.03.021

摘要

坏死性凋亡是新近发现的一种程序性坏死途径，在死亡受体信号激活后由RIP1和RIP3调控，并可被化合物necrostatin-1特异性抑制。目前研究证实坏死性凋亡涉及多种中枢神经系统损伤疾病的发生机制，并且通过干预坏死性凋亡信号通路，对诸多因素引起的中枢神经系统损伤具有一定的保护作用。深入研究坏死性凋亡的分子调控机制，有望为中枢神经系统损伤疾病治疗提供更多的潜在新靶点。
关键词： 坏死性凋亡 中枢神经系统 损伤

The advanced research of necroptosis and the central nervous system injured diseases

Authors: 1YANG Haiyu, 2LIU Yong
1 Institute of Clinical Medicial Sciences, Jiangxi Province People’s Hospital, Nanchang 330006, China
2 Department of Pathology, Jiangxi Province People’s Hospital, Nanchang 330006, China

CorrespondingAuthor: LIU Yong Email: jxpathology@126.com

DOI: 10.3978/j.issn.2095-6959.2016.03.021

Abstract

Necroptosis is a kind of programmed necrosis that is newly discovered and regulated by RIP1 and RIP3 after the activation of death receptor signaling pathway, and it can be specific inhibited by necrostatin-1, a small compound. The present study confirmed that necroptosis was involved mechanisms of a variety of central nervous system (CNS) damages, and intervention of necroptosis signaling pathways had certain protective effects on CNS injuries caused by many factors. Further study the regulatory mechanism of necroptosis is expected to be provided more potential new targets for the treatment of the CNS injured diseases.

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