胰岛素受体底物家族成员的结构和组织特异性与功能的关系
| 作者: |
1唐辰义,
1周后德
1 中南大学湘雅二医院代谢内分泌研究所，长沙 410011 |
| 通讯: |
周后德
Email: houdezhou@csu.edu.cn |
| DOI: | 10.3978/j.issn.2095-6959.2016.03.016 |
| 基金: | 国家自然科学基金, 81370975 湖南省杰出青年基金项目, 100JJ1007 |
摘要
胰岛素(insulin)/胰岛素样生长因子1(insulin-like growth factor 1，IGF-1)信号通路在细胞的分化、生长、生存及代谢起非常重要作用。胰岛素信号传递首先需要胰岛素/IGF-1与胰岛素受体(insulin receptor，IR)结合，磷酸化胰岛素受体底物(insulin receptor substrates，IRSs)后形成一个紧密连接的三聚物。磷酸化的IRSs作为停靠蛋白(docking protein)再激活一系列包含Src同源结构域2(SH2)的蛋白，引起相应的生物学效应。目前发现IRSs从IRS-1到IRS-6共6种，它们的分布存在明显的组织特异性，IRS-1、2在人体多种组织中分布广泛；IRS-3则在脂肪组织中居多；而IRS-4、5、6在人体组织表达相对较低。本文拟对IRSs在组织中分布特异性与功能作一综述。
关键词：
胰岛素受体底物蛋白1-6
Src同源结构域2
胰岛素信号通路
Tissue specific functions of insulin receptor substrate family members based on their molecular structures
CorrespondingAuthor: ZHOU Houde Email: houdezhou@csu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2016.03.016
Abstract
Insulin/Insulin-like growth factor 1 (IGF-1) signaling pathway plays important roles in cell differentiation, growth, survival and metabolism. Firstly, insulin/IGF-1 binds with insulin receptor to phosphorylate insulin receptor substrates (IRSs), which forms a tightly coupled trimer and then the phosphorylated IRSs activate a series of downstream Src homology 2 (SH2) containing proteins such as docking proteins, and then initiated a series of corresponding biological effects on target cells. There are 6 members in IRSs family from IRS-1 to IRS-6 among which the distribution is distinct from each other in various tissues. IRS-1 and IRS-2 distribute widely in different tissues and IRS-3 expresses more in adipose tissue while IRS-4, IRS-5 and IRS-6 distribute very few in human tissues. Here we summarized the tissue specific functions of insulin receptor substrate family members based on their molecular structures.