1 575例胃肿瘤临床病理特征分析
| 作者: |
1王海艳,
1许春伟,
1邵云,
1张博,
1邰艳红,
1李晓兵,
2徐建明,
3吴世凯,
4李虎城,
4尉承泽
1 军事医学科学院附属医院病理科，北京 100071 2 军事医学科学院附属医院消化道肿瘤科，北京 100071 3 军事医学科学院附属医院放疗科，北京 100071 4 军事医学科学院附属医院普外科，北京 100071 |
| 通讯: |
王海艳
Email: 1141554200@qq.com 许春伟 Email: xuchunweibbb@163.com 邵云 Email: shysep@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.12.015 |
摘要
目的：根据WHO(2010版)消化系统胃肿瘤分类标准，探讨分析军事医学科学院附属医院胃肿瘤的病理类型及分布特点。方法：收集2010年11月至2015年3月军事医学科学院附属医院诊治的1 575例胃肿瘤，并复习其临床资料、HE及免疫组织化学切片，按WHO(2010版)分类标准进行病理诊断及分类。结果：1 575例胃肿瘤中，多数为男性患者(1 048例)，约占66.54%，女性患者527例，约占33.46%。胃良性肿瘤25例(1.59%)、上皮内瘤变553例(35.11%)、胃癌893例(56.70%)、神经内分泌肿瘤24例(1.52%)、混合性腺神经内分泌癌3例(0.19%)、淋巴瘤20例(1.27%)、间叶性肿瘤47例(2.98%)、纤维上皮性肿瘤1例(腺肌瘤0.06%)、继发性肿瘤9例(0.57%)。胃癌中，管状腺癌明显居多(640例)，占上皮性恶性肿瘤的71.67%，其次为混合癌(209例)，占上皮性恶性肿瘤的23.40%。胃癌中分子亚型分类HER2 FISH阳性表达的有53例，阴性表达的有586例，未做检测的有254例，总体阳性率为8.29%。结论：胃部肿瘤种类多样，其中胃癌的发病率占明显优势，但其缺乏特征性的临床表现使大多数患者就诊时已处于中晚期，因此内窥镜检查对于胃癌高危人群的筛查尤为重要，以便早发现、早治疗。
关键词：
胃癌
管状腺癌
印戒细胞癌
临床病理分析
1 575 cases of clinicopathological characteristics analysis of gastric neoplasm
CorrespondingAuthor: WANG Haiyan Email: 1141554200@qq.com
DOI: 10.3978/j.issn.2095-6959.2015.12.015
Abstract
Objective: To analyze clinicopathological features and observe the pathological types and distribution among gastric neoplasms of the digestive system in Affiliated Hospital of Academy of Military Medical Sciences, according to the World Health Organization criteria (2010). Methods: A retrospective analysis of 1 575 cases of gastric neoplasms, which was diagnosed by authors, from November 2010 to March 2014. All the histopathological slides including HE slides and immunohistochemistry slides were re-examined and the medical records were reviewed. Results: Among the 1 575 cases, most patients were males (1 048 cases), which account for 66.54%, and rare cases were females (527 cases), which account for 33.46%. A total of 25 cases were benign tumors(1.59%), 553 cases were intraepithelial neoplasias (35.11%), 893 cases were gastric cancers (56.70%), 24 cases were neuroendocrine tumors (1.52%), 3 cases were mixed adeno-neuroendocrine cancers (0.19%), 20 cases were lymphomas (1.27%), 47 cases were mesenchymal tumors (2.98%), 1 case was adenomyoma (0.06%) and 9 cases were secondary tumors (0.57%). Most gastric cancers were tubular adenocarcinomas (640 cases, 71.67%), the next were mixed carcinomas (209 cases, 23.40%). There were 53 cases showed Her-2 FISH positive, 586 cases showed negative and 254 cases were not acquired in detail, the total rate of Her-2 positive were 8.29%. Conclusion: There were many kinds of tumors in gastric, and most of which were malignant, but most patients were aggressive-phase when they were checked for inadequate distinctive clinical manifestations, so, it is important to promote the early diagnosis of gastric cancer by endoscope for early discovery and treatment.