可溶性白细胞分化抗原40配体在冠状动脉慢血流中的作用及其与黏附分子的相关性
| 作者: |
1徐文,
2张津津
1 上海市普陀区利群医院心内科，上海 200333 2 复旦大学附属华山北院心内科，上海 201907 |
| 通讯: |
徐文
Email: xwuen@sina.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.12.016 |
摘要
目的：探讨可溶性白细胞分化抗原40配体(soluble cluster of differentiation 40 ligand，sCD40L)在冠状动脉慢血流中的作用及其与黏附分子的相关性。方法：ELISA分析80例冠状动脉慢血流患者和20例正常对照者血清中sCD40L以及黏附因子ICAM-1、VCAM-1的水平，并分析其相关性。结果：冠脉慢血流患者血清sCD40L、ICAM-1和VCAM-1均明显高于正常组，差异具有统计学意义(均为P<0.01)。相关分析显示血清中sCD40L的水平与黏附分子VCAM-1和ICAM-1的水平均具有正相关性。结论：sCD40L可能通过促进黏附分子的表达参与冠状动脉慢血流的发生发展。
关键词：
sCD40L
黏附分子
冠状动脉慢血流
Role of soluble cluster of differentiation 40 ligand in slow coronary flow and its correlation with adhesion molecules
CorrespondingAuthor: XU Wen Email: xwuen@sina.com
DOI: 10.3978/j.issn.2095-6959.2015.12.016
Abstract
Objective: To explore the role of soluble cluster of differentiation 40 ligand (sCD40L) in slow coronary flow, and its correlation with adhesion molecules. Methods: The serum levels of sCD40L and related adhesion molecules: ICAM-1 and VCAM-1 in 80 patients with slow coronary flow and 20 normal subjects were analyzed. Results: The serum levels of sCD40L, VCAM-1 and ICAM-1were significantly higher in patients with slow coronary flow than those in normal group respectively (P<0.01, respectively). Correlation analysis showed that the sCD40L level was positively associated with the expression levels of VCAM-1 and ICAM-1, respectively. Conclusion: sCD40L may participate in the development of slow coronary flow by improving the expression of ICAM-1 and VCAM-1.