血糖控制不佳的2型糖尿病患者胰岛β细胞分泌功能的特点研究
| 作者: |
1袁心露,
1朱晓晖,
1崔世维
1 南通大学附属医院内分泌科，江苏 南通 226001 |
| 通讯: |
袁心露
Email: yuanxinlu1982@126.com 崔世维 Email: 2231726492@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.11.024 |
摘要
目的：分析血糖控制不佳的2型糖尿病(type 2 diabetes mellitus，T2DM)患者胰岛β细胞分泌功能的特点。方法：430例T2DM患者根据血糖化血红蛋白(HbA1C)水平分为三组，行胰岛素释放试验，并根据相应公式计算反映胰岛β细胞功能的指标，分析三组差异；结果：随着血HbA1c水平增高，血糖水平增高，其曲线下面积(area under curve，AUC)增大(P<0.05)；C肽和胰岛素水平减低，AUC减少(P<0.05)；血糖控制不佳时，HOMAβ、MBCI、IGI30、DI、SUIT 0 min、SUIT 120 min和CPR index减小，除MBCI值在7%10%组间差异无统计学意义外，其他的指标在三组间差异均有统计学意义(P<0.05)。结论：血糖控制对于胰岛β细胞分泌功能的保护至关重要。
关键词：
2型糖尿病
胰岛β细胞
糖化血红蛋白
胰岛素释放试验
The investigation of insulin secretion function of pancreas β cells in poor glucose control type 2 diabetic patients
CorrespondingAuthor: YUAN Xinlu Email: yuanxinlu1982@126.com
DOI: 10.3978/j.issn.2095-6959.2015.11.024
Abstract
Objective: To assess the insulin secretion function of pancreas β cells in T2DM patients with poor glucose control. Methods: A total of 430 T2DM patients were randomly divided into 3 groups according to their serum HbA1c level. Insulin releasing test was manipulated and index suggesting insulin secretion function of pancreas β cells were calculated. Results: The level of glucose and area under curve (AUC) were increased and those of insulin and c-peptide were decreased as HbA1c was increased. HOMAβ, MBCI, IGI30, DI, SUIT 0 min, SUIT 120 min and CPR index all reduced followed with poor controlled glucose. Conclusion: Suitable glucose management is vital for the protection of insulin secretion function in pancreas β cells for T2DM patients.