2型糖尿病肾病患者Cys C、血管内皮生长因子和β2-GPⅠ水平的检测及其临床意义
| 作者: |
1李剑,
1闫双通,
1龚燕平,
1卢艳慧,
1孙般若,
1成晓玲,
1李春霖,
1邵迎红
1 解放军总医院老年内分泌科，北京 100853 |
| 通讯: |
邵迎红
Email: shaoyinghong1968@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.11.029 |
摘要
目的：探讨2型糖尿病肾病患者血清胱抑素C(Cystain C，CysC)、血管内皮生长因子和β2糖蛋白I(β2-glycoprotein，β2-GPⅠ)水平及其检测临床意义。方法：100例患者按尿白蛋白排泄率(UMER)分为正常蛋白尿组(UMER<30 mg/24 h，n=40)、微量白蛋白尿组(30 mg/24 h≤UMER<300 mg/24 h，n=30 )和临床白蛋白尿组(UMER≥300 mg/24 h，n=30)。比较三组患者CysC、血管内皮生长因子和β2-GPⅠ水平，并行相关性线性分析和Logistic回归分析。结果：与正常蛋白尿组比较，糖尿病肾病组的CysC、血管内皮生长因子和β2-GPⅠ水平更高(P<0.05)，与微量白蛋白尿组比较，临床蛋白尿组的CysC、血管内皮生长因子和β2-GPⅠ水平更高(P<0.05)；线性相关性分析结果显示，CysC(r1=−0.532，P<0.05；r2=−0.483，P<0.05)、血管内皮生长因子(r1=−0.237，P<0.05；r2=−0.232，P<0.05)和β2-GPⅠ水平(r1=−0.713，P<0.05；r2=−0.633，P<0.05)与肾小球滤过率和白蛋白呈负相关性，与患者的UEMR(r1=0.337，P<0.05；r2=0.437，P<0.05；r3=0.534，P<0.05)和视网膜病变(r1=0.635，P<0.05；r2=0.353，P<0.05；r3=0.538，P<0.05)呈正相关性；多因素分析显示是否患有糖尿病肾病与患者的CysC、血管内皮生长因子和β2-GPⅠ水平显著相关(P<0.05)。结论：CysC、血管内皮生长因子和β2-GPⅠ水平较敏感反映糖尿病肾脏病变。
关键词：
2型糖尿病肾病
CysC
血管内皮生长因子
β2-GPⅠ
The clinical examination significance of CysC, vascular endothelial growth factor and levels β2-GPⅠon type 2 diabetic nephropathy
CorrespondingAuthor: SHAO Yinghong Email: shaoyinghong1968@126.com
DOI: 10.3978/j.issn.2095-6959.2015.11.029
Abstract
Objective: To explore clinical examination significance of type 2 diabetic patients with nephropathy CysC, vascular endothelial growth factor and β2-GPⅠ levels. Methods: 100 patients according to urinary albumin excretion rate (umer) divided into normal albuminuria group (UMER<30 mg/24 h, n=40), microalbuminuria group (30 mg/24 h was less than or equal to UMER<300 mg/24 h, n=30) and clinical albumin urinary group (umer was more than or equal to 300 mg/24 h, n=30). CysC, vascular endothelial growth factor and beta 2-GP I level in the three groups were compared with the linear analysis and Logistic regression analysis. Results: Compared with normal albuminuria group, diabetic nephropathy group of CysC, vascular endothelial growth factor and beta 2-GP Ⅰ higher levels (P<0.05), compared with microalbuminuria group, clinical albuminuria group of CysC, vascular endothelial growth factor and beta 2 - GP Ⅰ higher levels (P<0.05); Linear correlation analysis, according to the results of CysC (r1=0.532, P<0.05; r2=0.483, P<0.05), vascular endothelial growth factor (r1=0.237, P<0.05; r2=0.232, P<0.05) and beta 2-GP Ⅰ levels (r1=0.713, P<0.05; r2=0.633, P<0.05) and negatively correlation with glomerular filtration rate and albumin, and the patient's UEMR (r1=0.337, P<0.05; r2=0.437, P<0.05; r3= 0.534, P<0.05), and retinopathy (r1=0.635, P<0.05, r2=0.05, P<0.05, r3=0.538, P<0.05) there was a positive correlation; Multiple factors analysis showed that whether diabetic kidney. Conclusion: CysC, vascular endothelial growth factor and 2-GP I level are more sensitive than that of diabetic nephropathy.