FoxQ1在不同级别脑胶质瘤组织的表达和临床意义
| 作者: |
1蒋蔚,
2王新
1 无锡市第二人民医院脑科中心, 无锡 江苏 214000 2 南通大学神经再生研究所, 南通 江苏 226001 |
| 通讯: |
蒋蔚
Email: jiangwei2703@aliyun.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.10.015 |
| 基金: | 国家自然科学基金青年基金, 31400918 |
摘要
目的：研究FoxQ1在不同级别脑胶质瘤组织中的表达和临床意义。方法：在组织水平，使用免疫组织化学法检测92例不同级别胶质瘤组织中FoxQ1的表达，并分析FoxQ1表达与临床病理参数及预后的关系。结果：FoxQ1在34例低级别星形细胞瘤(WHOⅠ~Ⅱ级)、35例间变性星形细胞瘤(WHOⅢ级)和23例胶质母细胞瘤(WHO Ⅳ级)组织中的阳性表达率分别为：14.70%、65.71%和91.30%，差异有统计学意义(χ2=35.85，P<0.01)。胶质瘤组织中FoxQ1表达与WHO分级相关(P<0.05)。经Kaplan-Meier法生存比较，FoxQ1的阳性表达者比阴性表达者生存期短(P<0.05)。多因素分析显示FoxQ1表达是胶质瘤患者独立的预后指标。结论：FoxQ1异常表达可能参与胶质瘤的发生发展和预后相关，并有望成为评估胶质瘤预后的有效指标。
关键词：
胶质瘤
FoxQ1
预后
Expression and clinical significance of FoxQ1 in glioma development and progression
CorrespondingAuthor: JIANG Wei Email: jiangwei2703@aliyun.com
DOI: 10.3978/j.issn.2095-6959.2015.10.015
Abstract
Objective: To investigate the role of FoxQ1 in different grade Glioma and analyze the clinical significance. Methods: Immunohistochemical method was used to detect the expression of FoxQ1 in 92 cases of glioma tissue, and then its relationship between clinicopathological features and prognosis was analyzed. Results: The positive expression rate of FoxQ1 protein in 34 low-grade astrocytomas, 35 anaplastic astrocytomas, and 23 glioblastoma multiforme specimens were 14.70 %, 65.71 % and 91.30 % respectively (χ2=35.85, P<0.01). FoxQ1 expression had significantly correlations with WHO grade (P< 0.05). The results of Kaplan-Meier survival analysis indicated that positive expression of FoxQ1 were associated with a worse survival (P<0.05). Multivariate analysis indicated that FoxQ1 expression was an independent prognostic factor for overall survival (P<0.05). Conclusion: The abnormal expression of FoxQ1 might be correlated with the development and progression of Glioma. FOXQ1 might be an indicator to predict the prognosis of Glioma.