FoxQ1在食管鳞状细胞癌中的表达及其与预后
| 作者: |
1姚宁华,
2盖领,
3黄华,
4袁心露,
5王新
1 南通大学附属医院肿瘤放疗科，江苏 南通 226001 2 南通大学附属医院肿瘤化疗科，江苏 南通 226001 3 南通大学附属医院肿瘤病理科，江苏 南通 226001 4 南通大学附属医院内分泌科，江苏 南通 226001 5 南通大学神经再生研究所，江苏 南通 226001 |
| 通讯: |
姚宁华
Email: yaonh2009@163.com 袁心露 Email: yuanxinlu1982@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.09.011 |
摘要
目的：研究FoxQ1在食管鳞状细胞癌组织中的表达及其与临床病理特征和预后的关系。方法：在组织水平，应用免疫组织化学En Vision法检测91例食管鳞状细胞癌组织及相应癌旁组织FoxQ1的表达， 并分析其表达与临床病理特征及预后之间的关系。结果：1) FoxQ1在食管鳞状细胞癌组织及配对正常食管组织中的阳性表达率分别为：62.6%(57/91)和23.1%(21/91)，差异有统计学意义(P<0.05)； FoxQ1的表达与肿瘤浸润深度、临床分期及预后相关(P<0.05)。经Kaplan-Meier法生存比较，FoxQ1的阳性表达者比阴性表达者生存期短(P<0.05)；多因素Cox比例风险模型分析显示，FoxQ1可以作为判断食管鳞状细胞癌预后的独立因素(P<0.05)。结论：FoxQ1在食管鳞状细胞癌组织中高表达，其表达水平与食管鳞癌发生发展及预后密切相关。有望成为评估食管鳞状细胞癌预后的有效指标。
关键词：
食管鳞状细胞癌
FoxQ1
预后
Expression and prognosis of FoxQ1 in esophageal squamous cell carcinoma
CorrespondingAuthor: YAO Ninghua Email: yaonh2009@163.com
DOI: 10.3978/j.issn.2095-6959.2015.09.011
Abstract
Objective: To investigate the expression of FoxQ1 in esophageal squamous cell carcinoma (ESCC) and analyze their clinical significance, and to evaluate the correlation with prognosis. Methods: Immuno-histochemical method was used to detect the expression of FoxQ1 in 91 cases of ESCC tissues and adjacent normal esophageal tissues. χ2 test was used to analyze their correlations with the clinicopathologic factors and prognosis of ESCC patients. Results: The expression of FoxQ1 was significantly higher in ESCC than that in normal esophageal tissues (62.6% vs 23.1%, P<0.05). FoxQ1 expression had significantly correlations with invasive depth, clinical stage and prognosis (P<0.05). The results of Kaplan-Meier survival analysis indicated that positive expression of FoxQ1 were associated with a worse survival (P<0.05). Conclusion: FoxQ1 was highly expressed in ESCC and significantly correlated with prognosis of esophageal cancer; FOXQ1 might be an indicator to predict the prognosis in esophageal cancer.