PRC2成分SUZ12在结直肠癌组织中的表达及其临床意义【已撤稿】
| 作者: |
1苏永辉,
1侯冰宗,
1徐家琪,
1卜巨源,
1李宵凌
1 中山大学附属第五医院普通外科，广东 珠海 519000 |
| 通讯: |
侯冰宗
Email: houbingzong@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.06.S005 |
| 基金: | 珠海市科技计划项目, 02198811140711028 |
摘要
【本文已撤稿，请勿继续引用】目的：探讨PRC2成分SUZ12在结直肠癌组织中的表达及其与临床病理特征的关系。方法：应用免疫组织化学技术检测检测2012年6月至2013年6月我院76例结直肠癌患者手术切除的肿瘤组织和配对癌旁正常组织中SUZ12的表达，分析SUZ12与结直肠癌临床病理特征的相关性。结果：SUZ12在结直肠癌组织表达水平(9.24±4.47)明显高于配对的正常结直肠组织(3.45±2.78)，两者差异有统计学意义(P<0.01)，SUZ12表达水平与结直肠癌组织学分化程度(P=0.014)、TNM分期(P=0.016)及淋巴结转移(P=0.036)有关，而与患者的年龄、性别、肿瘤的部位、大小及浸润深度无明显相关(P>0.05)。结论：SUZ12表达与结直肠癌侵袭和转移密切相关，可以作为评估结直肠癌恶性程度新的指标。
关键词：
SUZ12
结直肠癌
免疫组织化学
The expression and clinical significance of polycombrepressive complex 2 component SUZ12 in colorectal cancer
DOI: 10.3978/j.issn.2095-6959.2015.06.S005
Abstract
Objective: To investigate the role of polycomb-repressive complex 2 component SUZ12 in colorectal cancer. Methods: Expression of SUZ12 was studied in archived specimens from 76 colorectal cancer patients by immunohistochemistry. Relationships between SUZ12 expression and clinicopathological characters were analyzed. Results: Expression of SUZ12 protein in colorectal cancer tissues was significantly higher than that in paratumor tissues (9.24±4.47 vs. 3.45±2.78, P<0.01). SUZ12 expression was significantly correlated with tumor differentiation (P=0.014), TNM stage (P=0.016) and lymph nodes metastasis (P=0.036), but not with the patients age, gender, tumor location, tumor size or tumor invasion(P>0.05). Conclusion: Over expression of SUZ12 is associated with more aggressive colorectal cancer and might be a biomarker for metastatic colorectal cancer.