Similarities and differences of procedures of clinical trials coexist due to different biological behaviors of cancers. It is quite inspiring to explore the most optimal treatment according to different tumors’ characteristics of genesis, progression and response to therapies, if we could push boundaries of different tumors, evaluate internal disciplines and critical junctures comprehensively under a common treatment modality among multiple disciplines. This considerably matters for physicians from different fields to learn from and enlighten each other when performing clinical trials and clinical practices. Nowadays, neoadjuvant therapy has been laid increasing emphasis on during clinical practices and corresponding trials have been conducted among different disciplines of oncology. Members of the Youth Committee of Chinese Society of Clinical Oncology (CSCO) have discussed experiences of neoadjuvant treatment modalities of different cancers to explore better strategies.