P504S在前列腺癌、肾细胞癌和膀胱尿路上皮癌中的表达及临床意义
| 作者: |
1马志伟,
2董丹丹,
1龚百生,
1邱明星
1 四川省医学科学院·四川省人民医院泌尿外科，成都 610072 2 四川省医学科学院·四川省人民医院病理科，成都 610072 |
| 通讯: |
邱明星
Email: 1303624874@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.07.014 |
| 基金: | 四川省甲级重点学科（泌尿外科）建设项目（2015） |
摘要
目的：探讨肿瘤标记物P504S在前列腺癌(prostate cancer，Pca)、肾细胞癌(renal cell carcinoma，RCC)和膀胱尿路上皮癌(bladder transitional cell carcinoma，BTCC)组织中的表达及临床意义。方法：采用免疫组织化学标记菌葡萄聚糖聚合物法(labeled dextran polymer，LDP)，检测P504S在前列腺癌、肾细胞癌和膀胱尿路上皮癌组织中的表达情况，探讨其在前列腺增生(benign prostatichyperplasia，BPH)组织、正常肾组织和正常膀胱组织中的表达并作相应比较。结果：P504S在Pca、RCC和BTCC组织中阳性表达率分别为93.10%、65.28%和46.07%，而在BPH、正常肾组织和正常膀胱组织分别为0%、6.67%和6.25%，各组间差异均有统计学意义(P<0.01)；P504S阳性表达水平与Pca、RCC及BTCC病理分级和临床分期均呈正相关(P<0.05)，与肿瘤的预后也密切相关。结论：P504S的表达水平可较好地反映前列腺癌、肾细胞癌和膀胱尿路上皮癌生物学行为，可作为判断肿瘤侵袭、病情发展及预后指标之一。
关键词：
前列腺癌
肾细胞癌
膀胱尿路上皮癌
α-甲基酰基辅酶A消旋酶
免疫组织化学
The expression of P504S in prostate adenocarcinoma, renal cell carcinoma and bladder urothelial carcinoma and its clinical significances
CorrespondingAuthor: QIU Ming-xing Email: 1303624874@qq.com
DOI: 10.3978/j.issn.2095-6959.2015.07.014
Abstract
Objective: To evaluate the expression and clinical significance of P504S in prostate cancer (Pca), renal cell carcinoma (RCC) and bladder transitional cell carcinoma (BTCC). Methods: Immunohistochemical labeled dextran polymer (LDP) methods were used to detect the expressions of P504S in Pca, RCC and BTCC, and also to analyze the difference of expressions in benign prostatic hyperplasia tissue, normal renal tissue and normal bladder tissues. Results: The positive expression rates of P504S in Pca, RCC and BTCC tissues were 93.10%, 65.28% and 46.07% respectively, but in BPH tissue, normal renal tissue and normal bladder tissue were 0%, 6.67% and 6.25% respectively, the expression was significantly different (P<0.01). The positive expression levels of P504S were positively correlated to tumor pathological grades and tumor clinical stages (P<0.05) of Pca, RCC and BTCC. It was also closely correlated with the prognosis of tumor. Conclusion: It suggested that P504S might play a role in the biological behavior of Pca, RCC and BTCC and might serve as an important indicator of the invasion, development and prognosis of these tumors.