Objective: To investigate the combined clinical effect of progynova and cervical injection of lidocaine in postmenopausal women. Methods: A total of 300 postmenopausal women from Jan 2012 to May 2014 in family planning clinic were divided into three groups randomly, 100 patients each group, group A was given oral progynova 2 mg for 7 days prior to surgery; group B was given cervical injection of 2% lidocaine prior to surgery; group C was given oral progynova 2 mg for 7 days combined with cervical injection of 2% lidocaine prior to surgery. Compared of three groups with cervical relaxation, cervical elasticity, operation pain, operation time, intraoperative bleeding volume, IUD removal difficulty, and failure rate. Results: Group C, the degree of cervical relaxation and cervical elasticity is better than the other two groups, operation time is shorter than the other two groups, the degree of pain is lower than the other two groups, the amount of bleeding is less than the other two groups, no removal difficulties and failure, was statistically significant difference (P<0.05). Conclusion: Progynova combined with cervical injection of lidocaine is beneficial to postmenopausal women cervical relaxation, relieve pain in postmenopausal women, is worthy of clinical application.