鼻腔平滑肌肉瘤1例及文献复习
| 作者: |
1张冬梅,
2魏建国,
3杨建峰
1 北京市宣武中医医院病理科，北京 100050 2 浙江省绍兴市人民医院 病理科，浙江绍兴 312000 3 浙江省绍兴市人民医院 放射科，浙江绍兴 312000 |
| 通讯: |
张冬梅
Email: dongmeigy@163.com 魏建国 Email: mickmouse88@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.04.033 |
摘要
目的：探讨鼻腔平滑肌肉瘤(leiomyosarcoma，LMS)的临床病理特征及鉴别诊断。方法：观察1例鼻 腔原发LMS的临床表现、组织学特征和免疫组化特点，并复习相关文献。结果：患者，男，62岁， 因左鼻塞流涕2月余入院，术后结果显示肿瘤由梭形细胞束组成，细胞核呈卵圆形或短梭形，两端 钝圆，部分细胞核仁肥胖，胞浆嗜酸性，染色质粗糙；细胞核异型性明显，核分裂3~5个/10HPF， 间质可见粘液变性，部分区域可见坏死。免疫组化显示瘤细胞SMA、Vimentin、Calponin和Desmin 均(+)。结论：平滑肌肉瘤是鼻及鼻窦部分少见的软组织恶性肿瘤，侵袭性较高，临床预后较差。
关键词：
平滑肌肉瘤
鼻腔鼻窦
免疫组化
Leiomyosarcoma of nasal cavity: a case report and literature review
CorrespondingAuthor: ZHANG Dongmei Email: dongmeigy@163.com
DOI: 10.3978/j.issn.2095-6959.2015.04.033
Abstract
Objective: To explore the clinicopathologic feature and differential diagnosis of leiomyosarcoma (LMS) of the nasal cavity. Methods: The clinical, histopathological and immunohistochemical features of one cases of LMS of nasal cavity were analyzed and the literatures were reviewed. Results: A male patient, 62 years old, more than a month of left nasal obstruction and rhinorrhea. Pathological examination showed that the tumor tissue comprised of fascicles of spindle-shaped cells with eosinophilic cytoplasm and oval to elongate and blunt ended vesicular nuclei. Mitosis was conspicuous. Areas of necrosis were seen. The focal stroma was mucoid degeneration. Tumor cells expressing SMA, Vimentin, Calponin and Desmin. Conclusion: LMS is a rare soft tissue cancer in nosal cavity and paranasal sinuses, high invasiveness and poor prognosis.