Treg/Th17与慢性阻塞性肺疾病的研究进展
| 作者: |
1,2田静,
2戴爱国,
2蒋永亮
1 南华大学附属马王堆医院 长沙 410016 2 湖南省老年医院呼吸疾病研究室 长沙 410016 |
| 通讯: |
戴爱国
Email: daiaiguo2003@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.01.032 |
| 基金: | 湖南省科技计划项目, 2011FJ6048 湖南省科技计划重点项目, 2012SK2006 |
摘要
慢性阻塞性肺疾病(chronic obstructive pulmonar y disease，COPD)是气道的炎性病症，以慢性 进展和不可逆的气流受限为特征。研究表明自身免疫反应参与本病的发病机制。调节性T细胞 (regulatory T-cells，Treg)和辅助性T细胞17(T helper 17 cells，Th17)是CD4+ T淋巴细胞的两个亚 群，是已知的重要的免疫调节细胞，牵涉到多种炎性和自身免疫性疾病的发病机理，并在气道炎 症和慢性阻塞性肺病的发病机制中起到重要作用。两者在功能和分化过程中相互拮抗，该平衡关 系的维持或破坏对于免疫或炎症性疾病的发病具有重要意义。
关键词：
调节性T细胞
辅助性T细胞17
慢性阻塞性肺疾病
Research progress of Treg/Th17 and chronic obstructive pulmonary disease
CorrespondingAuthor: DAI Aiguo Email: daiaiguo2003@163.com
DOI: 10.3978/j.issn.2095-6959.2015.01.032
Abstract
Chronic obstructive pulmonary disease (COPD) is a kind of disease about airway inflammation. It is a disease state characterized by airflow limitation that is not fully reversible and is progressive slowly. Recent research indicates that autoimmune reaction involved in the pathogenesis of this disease. CD4+ T-lymphocytes includes regulatory T-cells (Treg) and T helper 17 cells (Th17), which are both important immune regulatory cells and then involved in a series of pathogenesis of inflammatory and autoimmune related disease, furthermore play an important role in the pathogenesis of airway inflammation and chronic obstructive pulmonary disease. They are mutually antagonistic in function and differentiation, once the balance relationship is destroyed, it will have very important significance in immune or inflammatory disease.