1-磷酸鞘氨醇与肺部疾病的研究进展
| 作者: |
1戴芳芳,
2朱黎明,
2戴爱国
1 南华大学附属省马王堆医院，长沙 410016 2 湖南省老年医院呼吸疾病研究室，长沙 410016 |
| 通讯: |
朱黎明
Email: zhuliming3298@sina.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.01.026 |
| 基金: | 国家自然基金项目, 81270093 湖南省科技计划项目, 2012FJ3075 湖南省自然科学基金, 12JJ3111 湖南省 医药卫生科研计划课题, B2013-064 |
摘要
1-磷酸鞘氨醇(sphingosine-1-phosphate，S1P)是一种具有生物活性的细胞膜的重要组成部分以及鞘脂 类代谢产物之一。S1P也是调节细胞内外多种生物学功能的重要信号分子，通过与5种G蛋白偶联 受体亚型结合(即S1PR1-S1PR5)产生不同的生物学功能，包括调节细胞增殖、存活、凋亡、炎症诱 导及血管再生等。近年来研究表明S1P及其S1PR/SPHK对肺部疾病的发生发展起着重要的作用， 尤其对支气管哮喘、肺纤维化、肺炎、支气管扩张、慢性阻塞性肺病(chronic obstructive pulmonary disease，COPD)以及肺癌的发生发展起着关键的作用，这或许为肺部疾病的治疗提供一个新途径。
关键词：
1-磷酸鞘氨醇
鞘氨醇激酶
支气管哮喘
肺纤维化
肺炎
支气管扩张
慢性阻塞性肺病
肺癌
Research progress of sphingosine-1-phosphate and lung disease
CorrespondingAuthor: ZHU Liming Email: zhuliming3298@sina.com
DOI: 10.3978/j.issn.2095-6959.2015.01.026
Abstract
Sphingosine-1-phosphate is one of the important components of a biologically active membrane and sphingolipid metabolites. It is important signaling molecules which regulates many biological functions in intracellular and extracellular. S1P combining with five kinds of G protein-coupled receptor subtypes (S1PR1-S1PR5) have different biological functions, including the regulation of cell proliferation, survival, apoptosis, inflammation and angiogenesis. Recent studies show that S1P and S1PR/SPHK play the important role in the development of lung disease, especially in bronchial asthma, pulmonary fibrosis, pneumonia, bronchiectasis, chronic obstructive pulmonary disease (COPD) and lung cancer. These studies may provide a new approach for the treatment of lung diseases.